|
Matt Hemm, Ph.D. Assistant Professor Department of Biological Sciences Office: Smith 343 Lab: Phone: 410-704-2996
Fax: 410-704-2405 email: mhemm@towson.edu
Education: Post-doc National Institutes of Health Ph.D. Purdue University
B.S. College
of William and Mary Courses Taught: BIOL409 Molecular Biology lecture BIOL410 Molecular Biology laboratory
|
|
|
Research Interests:
My lab is focused on identifying and functionally characterizing proteins containing fifty or fewer amino acids. The prevalence and physiological function of such small proteins are poorly understood in any organism. To address these biological questions, we are using the model bacterium Escherichia coli. We have recently found that E. coli contains many more small proteins than had been previously predicted. Further analysis has shown that many of these proteins are expressed under specific environmental conditions, suggesting that they have interesting functions in the cell. Our current goals include continuing to characterize small protein function in E. coli, in particular those small proteins that are predicted to span the membrane with a single hydrophobic a-helix. These transmembrane small proteins make up the majority of small proteins identified in E. coli, and could be performing a wide range of functions at the membrane. Ultimately, the information we learn about E. coli small proteins will provide a foundation for investigating small protein abundance and function in both other bacteria species and eukaryotes.
Selected Peer-Reviewed Publications: Hemm MR, Paul BJ, Miranda-Rios J, Hobbs EC, Soltanzad N, Storz G (2010) Small stress response proteins in Escherichia coli: Proteins missed by classical proteomics studies. J Bac 192: 46-58.
Fozo EM*, Hemm MR*, Storz G (2008) Small toxic proteins and the antisense RNAs that repress them. Microbiol Mol Biol Rev 72: 579-589. (*authors contributed equally)
Hemm MR, Paul BJ, Schneider TD, Storz G, Rudd KE. (2008) Small membrane proteins found by comparative genomics and ribosome binding site models. Mol Micro 70: 1487-1501.
Hemm MR, Rider SD, Ogas J, Murphy DJ, Chapple C. (2004) Light induces de novo phenylpropanoid biosynthesis in Arabidopsis roots. Plant J 38: 765-778.
Rider SD, Hemm MR, Hostetler HA, Li H, Chapple C, Ogas J. (2004) Metabolic profiling of the Arabidopsis pkl mutant reveals selective derepression of embryonic traits. Planta 219: 489-499.
Hemm MR, Ruegger MO, Chapple C. (2003) The Arabidopsis ref2 mutant is defective in the gene encoding CYP83A1 and shows both phenylpropanoid and glucosinolate phenotypes. Plant Cell 15: 179-194.
Franke R, Humphreys JM, Hemm MR, Denault JW, Ruegger MO, Cusumano JC, Chapple C. (2002) The Arabidopsis REF8 gene encodes the 3-hydroxylase of phenylpropanoid metabolism. Plant J 30: 33-46.
Franke R, Hemm MR, Denault JW, Ruegger MO, Humphreys JM, Chapple C. (2002) Changes in secondary metabolism and deposition of an unusual lignin in the ref8 mutant of Arabidopsis. Plant J 30: 47-60.
Hemm MR, Herrmann KM, Chapple C. (2001) Atmyb4: A transcription factor general in the battle against UV. Trends Plant Sci 6: 135-136.
Ralph J, Lapierre C, Marita JM, Kim H, Lu F, Hatfield RD, Ralph S, Chapple C, Franke R, Hemm MR, Doorsselaere JV, Sederoff RR, O'Malley DM, Scott JT, MacKay JJ, Yahiaoui N, Boudet A, Pean M, Pilate G, Jouanin L, Boerjan W. (2001) Elucidation of new structures in lignins of CAD- and COMT-deficient plants by NMR. Phytochemistry 57: 993-1003.
Humphreys JM, Hemm MR, Chapple C. (1999) Ferulate 5-hydroxylase from Arabidopsis is a multifunctional cytochrome P450-dependent monooxygenase catalyzing parallel hydroxylations in phenylpropanoid metabolism. Proc Natl Acad Sci USA 96: 10045-10050.
Research Students Mentored at
|
|
|