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Clare Muhoro

Associate Professor
Organic Chemistry

Office: 514G Smith
Phone: (410)704-4827

Education B.Sc. (1993) St. Lawrence University, magna cum laude
Ph.D. (1999) Yale University
Teaching General Chemistry II (CHEM 111)
Essentials of Organic Chemistry (CHEM 330)
Organic Chemistry I,II (CHEM 331/332)
Research Novel Syntheses and Applications of Phosphorus- and Boron-Containing Bifunctional Ligands

We utilize highly efficient homogeneous catalysis to synthesize phosphanyl(organyl)borane compounds, and apply these molecules as ligands in the synthesis of transition metal complexes. These unique ligands can be applied as functional ligands e.g., as nucleophile binding agents, Lewis acid cocatalysts in polymerizations reactions or as monomers in the synthesis of uncommon Lewis Acid-Base polymers.

Undergraduate researchers conduct this work exclusively under inert-atmosphere on a Schlenk line and in a glove-box. The students characterize the compounds by proton, carbon, boron and phosphorus NMR spectroscopy, GC-MS, and IR and UV-Vis spectroscopies.

Mechanisms of Decomposition of Organic Pesticides in Aqueous Environments

The aquatic fate of organic pesticides depends on numerous parameters that are unique to a given aquatic system such as pH, temperature, dissolved oxygen content, metal ion content, and salinity. Our group is interested in investigating the pathways of decomposition of organic pesticides under specific conditions.

The research involves travel to study sites, located in tropical regions, to characterize the aquatic environments in which organic pesticides are found. The field work is followed by laboratory studies involving kinetic studies on pesticide degradation. Undergraduate students measure reaction rates using proton NMR and UV-Vis spectroscopies.
Selected Publications
  1. Thangavelu, S. G.; Hocker, K. E.; Cooke, S. R.; Muhoro, C. N. “Synthetic, Spectroscopic and Structural Studies of Two Novel Phosphanyl(organyl)borane Compounds” J. Organomet. Chem. 2008, 693, 562-566. Link to Full Article
  2. Divito, C.; Masoudi, S.; Davies, S.; Muhoro, C.N. “Decomposition of Formetanate Hydrochloride Acaricide in Aqueous Environments”, J. Agr. Food Chem. 2007, 55, 5377-5382. Link to Full Article
  3. Ivanovska, I.; Muhoro, C. N.; Irusta, P. I. “Anti-tumor Therapeutic Molecules Target the Programmed Cell Death Machinery”, Minirev. Med. Chem., 2006, 6, 1033-1042. Link to Full Article
  4. Cochran, J. C.; Prindle, V.; Young, H. A.; Kumar, M. H.; Tom, S.; Petraco, N. D. K.; Muhoro, C. N.; Kelley, B. “Alkyl- and Acyl-Substituted Vinylstannanes: Synthesis and Reactivity in Electrophilic Substitution Reactions”, Synth. React. Inorg. Met.-Org. Chem. 2002, 32, 885 Link to Full Article
  5. Hartwig J. F.; Muhoro C.N. “Mechanistic Studies of Titanocene-Catalyzed Alkene and Alkyne Hydroboration: Borane Complexes as Catalytic Intermediates”, Organometallics 2000, 19, 30-38. Link to Full Article
  6. Waltz K. M.; Muhoro C. N.; Hartwig J. F. “C-H Activation and Functionalization of Unsaturated Hydrocarbons by Transition-Metal Boryl Complexes”, Organometallics 1999, 18, 3383-3393. Link to Full Article
  7. Muhoro C. N.; He X. M.; Hartwig J. F. “Titanocene Borane Sigma-Complexes”, J. Am. Chem. Soc. 1999, 121, 5033-5046. Link to Full Article
  8. Hartwig J. F.; Muhoro C. N.; He X. M.; Eisenstein, O.; Bosque, R.; Maseras, F.; “Catecholborane Bound to Titanocene. Unusual Coordination of Ligand σ-Bonds”, J. Am. Chem. Soc. 1996, 118, 10936-10937. Link to Full Article
  9. Waltz, K. M.; He, X. M.; Muhoro, C. N.; Hartwig, J. F.; “C-H Activation and Functionalization of Unsaturated Hydrocarbons by Transition-Metal Complexes”, J. Am. Chem. Soc. 1995, 117, 11357-11358 Link to Full Article

Faculty & Staff

Department of Chemistry
Smith Hall 543
Towson University
8000 York Road
Towson, MD 21252