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Richard S. Preisler

Associate Professor & Chair
Biochemistry

Office: 547 Smith
Phone: (410)704-3055
E-mail: rpreisler@towson.edu

Website: http://pages.towson.edu/preisler

Education B.Sc. (1974) Brown University, magna cum laude
Ph.D. (1980) Stanford University
Postdoctoral associate (1980-1982) University of Pennsylvania
Teaching General Chemistry I,II (CHEM 110/111)
Biochemistry I (CHEM 351)
Research My research group is interested in the biophysics of DNA conformations, particularly in the transition between righthanded B-DNA and lefthanded Z-DNA. I am collaborating with Professor Alan Pribula in the Department of Chemistry on an investigation of the ability of various transition metal complexes to bind to DNA and induce the B-to-Z transition. We are studying the effects of ionic charge, hydrogen bonding potential and stereochemistry of complexes. Another interesting aspect of DNA conformation is hydration. My group has used the technique of osmotic stress, placing DNA in an environment with high concentrations of an osmolyte such as sucrose, to explore the effect of removal of water of hydration on the conformation. We use primarily the spectroscopic method of circular dichroism (CD) to analyze the DNA conformation.
Selected Publications
  1. R.S. Preisler, H.H. Chen, M.F. Colombo, Y. Choe, B.J. Short, Jr., and D.C. Rau. “The B-Form to Z-Form Transition of Poly(dG-m5dC) is Sensitive to Neutral Solutes through an Osmotic Stress”, Biochem. 1995, 34, 14400-14407. Link to Full Article
  2. N.B. McDonnell and R.S. Preisler. “Hydrophobic Moieties in Cations, Anions, and Alcohols Promote the B-to-Z Transition in Poly[d(G-C)] and Poly[d(G-m5C)]”, Biochem. Biophys Res. Comm. 1989, 164, 426-433. Link to Full Article
  3. R.S. Preisler “The B-DNA to Z-DNA Transition in Alkali and Tetraalkylammonium Salts Correlated with Cation Effects on Solvent Structure” Biochem. Biophys. Res. Comm., 1987, 148, 609-616. Link to Full Article
  4. R.S. Preisler, C. Mandal, S.W. Englander, N.R. Kallenbach, J. Frazier, H.T. Miles, and F.B. Howard “Premelting and the Hydrogen Exchange Open State in Synthetic RNA Duplexes” Biopolymers, 1984, 23, 2099-2125. Link to Full Article
  5. R.S. Preisler, C. Mandal, S.W. Englander, N.R. Kallenbach, J. Frazier, F.G. Howard, and H.T. Miles “Equilibrium and Kinetic Characteristics of the Low Temperature Open State in Polynucleotide Duplexes” in Biomolecular Stereodynamics, R. H. Sarma, ed., Adenine Press, 1981, 405-416.
  6. R.S. Preisler and W.F. Thompson “Evolutionary Sequence Divergence within Repeated DNA Families of Higher Plant Genomes. II. Derivative Analysis of Thermal Denaturation” J. Molecular Evolution, 1981, 17, 85-93. Link to Full Article
  7. R.S. Preisler and W.F. Thompson “Evolutionary Sequence Divergence within Repeated DNA Families of Higher Plant Genomes. I. Analysis of Reassociation Kinetics” J. Molecular Evolution, 1981, 17, 78-84. Link to Full Article

Faculty & Staff

Department of Chemistry
Smith Hall 543
Towson University
8000 York Road
Towson, MD 21252