Erik Silldorff

Professor

Erik Silldorff

Contact Info

Phone:
Office:
Science Complex, Room 5150J
Email:
Hours:
By Appointment Only

Education

B.A. Biology and Chemistry, University of Delaware
Ph. D. Physiology, University of Delaware

Areas of Expertise

Hormonal control of capillary blood flow in the mammalian kidney

Biography

Over the past several years I have focused on the development of a textbook in Human Physiology. The draft text was completed in 2020 and is now in production with Kendall Hunt Publishing. The book, titled Mechanisms and Logic in Human Physiology, will support courses for undergraduate students in Biology and Allied Health fields. This text will come to print (and electronic media) in 2021-22.

From the cover…

Mechanisms and Logic in Human Physiology provides students with a means to employ real comprehension and critical thinking, allowing them to engage the content meaningfully and effectively. Our approach emphasizes the “how” and the “why” behind physiology, demonstrating consistency in mechanism fundamentals and providing a wider perspective that makes concepts almost intuitive. Students learn to think from the standpoint of functional logic, tackling novel situations with critical and analytical minds. Reading this text is perfect training for students (and others!) interested in learning physiology via true understanding. Mastering the concepts and cognitive skills developed here will be excellent preparation for advanced study, teaching, research, or a medical career. 

My previous research interests and training are in cardiovascular and renal (kidney) physiology. As an undergraduate and graduate student at the University of Delaware, I worked in the area of comparative physiology of the renin-angiotensin system. Specifically, I studied the mechanisms of angiotensin II action on the vasculature and cardiac performance in reptiles, including the American alligator. As a post-doctoral fellow at both Penn State and University of Maryland medical schools I worked in the area of hormonal control of capillary blood flow in the mammalian kidney. Studies examined the contractile characteristics of the kidney microcirculation, specifically the descending vasa recta (a particular capillary network), to determine the potential for regulation of total and regional renal blood flow. Focus was on the effects and interactions of molecules acting in a paracrine or autocrine (local) manner within the cortex (outer region) and medulla (inner region) of the kidney. These blood flow studies provided information about the regulation of the urine concentrating mechanism, blood pressure control, and pathological conditions such as acute ischemic renal failure. Techniques utilized included in vitro microperfusion and videomicroscopy for the measurement of blood vessel contractility as well as fluorescent imaging and photometry for the measurement of cellular signaling events. Grants from the American Heart Association and NIH supported this research.

Courses Taught

  • BIOL 221/221L Human Anatomy and Physiology I
  • BIOL 222/222L Human Anatomy and Physiology II
  • BIOL 325 Animal Physiology
  • BIOL 342/343 Human Physiology I and II
  • BIOL 367 Endocrinology
  • BIOL 470 Advanced Physiology
  • BIOL 604 Mechanisms in Physiology
  • BIOL 606 Biochemical Adaptations