My laboratory investigates the molecular mechanisms of dietary compounds as preventive
strategies against human diseases, especially cancer and inflammation. In particular,
the micronutrient selenium and the proteins in which selenium is incorporated are
a major focus in our lab. Additional interests include human gene polymorphisms that
have been linked to variable cancer incidence and thus may be viable molecular targets
for therapy or prevention. These genes, among others, may be responsible for the individual
responses to dietary compounds. Other projects investigate the effects of diet on
the composition of the intestinal microbiome of mammals. Current projects include
the effects of selenium in inflammatory colitis, the role of the 15kDa selenoprotein
in colon tumorigenesis, and the effects of dietary changes on the gut microbiome.
Biological models utilized include, but are not limited to, in vitro (human and mouse
cells, tissue samples) and in vivo (mouse) models.
Peters KM, Galinn SE, and Tsuji PA (2016). Selenium: Dietary sources, human nutritional
requirements and intake across populations. In Selenium: Its molecular biology and
role in human health. (4th Edition) Hatfield DL, Schweizer U, Tsuji PA, Gladyshev
VN, Editors. Springer Science+Business Media, LLC, New York, NY. (in press)
Galinn SE and Tsuji PA. Quercetin and kaempferol ameliorate inflammation through Nrf2
and other signaling pathways (2016). In Broccoli: Cultivation, Nutritional Properties
and Effects on Health. Juurlink B, Editor. Nova Publishers, Hauppauge, NY.
Tsuji PA, Carlson BA, Anderson CB, Seifried HE, Hatfield DL, Howard MT* (2015). Dietary
selenium levels affect selenoprotein expression and support the interferon-γ and IL-6
immune response pathways in mice. Nutrients 7(8), 6529-6549.
Tsuji PA, Carlson BA, Yoo M-H, Naranjo-Suarez S, Xu X, He Y, Asaki E, Seifried HE,
Reinhold WC, Davis CD, Gladyshev VN, Hatfield DL (2015). The 15kDa selenoprotein and
thioredoxin reductase 1 promote colon cancer by different pathways. PLoS One. 10(4):e0124487
Tsuji PA, Stephenson KK, Wade KL, Liu H and Fahey J (2013). Structure-activity analysis
of flavonoids: direct and indirect antioxidant, and anti-inflammatory potencies and
toxicities. Nutrition and Cancer: An International Journal, Volume 65, Issue 7.