My laboratory primarily investigates the molecular mechanisms of colon cancer and
inflammation. In particular, the use of dietary compounds as preventive strategies
are of interest. Biological models utilized include in vitro (human and mouse cells, tissue samples) and in vivo (mouse) models. Current projects include:
1) The effects of the micronutrient selenium and the proteins in which selenium is incorporated,
in inflammatory colitis and colon tumorigenesis. Potential synergistic or antagonistic
mechanisms with other dietary compounds, such as the isothiocyanate sulforaphane,
are also investigated.
2) The effects of commonly consumed polyphenols in colon carcinogenesis and the hallmarks
of cancer. Potential synergistic or antagonistic mechanisms with other dietary compounds
are also of interest.
Additional interests include the intestinal/fecal microbiome of mammals. Currently,
we investigate the effects of dietary selenium, probiotics, or seasonal dietary changes
on the relative abundance of microbiota in a variety of mammals (domesticated, captive,
wild, or laboratory animals).
Peters KM, Carlson BA, Gladyshev VN, Tsuji PA (2018) Selenoproteins in colon cancer. Free Radical Biology & Medicine pii: S0891-5849(18)30908-0.
Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko
DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VN. (2018) Role of Selenof
as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins. Cell Rep. 23(5):1387-1398.
Peters KM, Galinn SE, and Tsuji PA (2016). Selenium: Dietary sources, human nutritional requirements and intake across
populations. In Selenium: Its molecular biology and role in human health. (4th Edition) Hatfield DL, Schweizer U, Tsuji PA, Gladyshev VN, Editors. Springer Science+Business Media, LLC, New York, NY.
Galinn SE and Tsuji PA. Quercetin and kaempferol ameliorate inflammation through Nrf2 and other signaling
pathways (2016). In Broccoli: Cultivation, Nutritional Properties and Effects on Health. Juurlink B, Editor. Nova Publishers, Hauppauge, NY.
BIOL 200 (Intro to Cell Biology and Genetics)
BIOL 411 (Cancer Biology)
BIOL 655 (Biology of Cancer, graduate)
BIOL 796 (Professional Aspects, graduate)
BIOL 797 (Graduate Seminar)